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How do I SLOW DOWN AGING?

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Violent Knife Stage
  04/22/18
sunscreen
Slate chapel
  04/22/18
The label says it may contain a carcinogen
Violent Knife Stage
  04/22/18
The sun is a verified carcinogen
Slate chapel
  04/22/18
Isn't sunscreen worse tho?
onyx floppy set
  04/22/18
Uh no? It's pretty much accepted as a necessary daily skin c...
Slate chapel
  04/22/18
DAILY??? Obvious Jew scam.
onyx floppy set
  04/22/18
lol who the fuck on this website is spending enough time in ...
Violent Orchestra Pit Goal In Life
  04/23/18
reduce stress
fiercely-loyal poppy dysfunction wrinkle
  04/22/18
I live in a joo dominated country full of niggers.
Violent Knife Stage
  04/22/18
Impossible.
judgmental diverse boistinker
  04/23/18
Rape children, drink their blood
thriller resort
  04/22/18
dont forget to harvest their adrenochrome
Claret bateful school cafeteria
  04/22/18
My first thought too.
onyx floppy set
  04/22/18
Meditate, ginseng, green tea, not eating processed shit, eat...
translucent field immigrant
  04/22/18
Sleep is the only thing from this list that matters
talented wine digit ratio
  04/23/18
And H2o, unfortunately.
titillating haunting business firm gaping
  04/23/18
lift weights. eat healthily. bang your wife often and vigo...
costumed associate trailer park
  04/22/18
Sleep a lot
bright office
  04/22/18
seems tcr
garnet rough-skinned legend
  04/22/18
...
contagious range persian
  04/23/18
calorie restriction
splenetic degenerate
  04/22/18
not worth it
costumed associate trailer park
  04/22/18
probably but its the only one with actual science
splenetic degenerate
  04/22/18
agree there. still not worth it.
costumed associate trailer park
  04/22/18
(guy who think studies on monkeys and worms necessarily tran...
histrionic keepsake machete abode
  04/22/18
(guy who think humans aren't monkeys)
Violent Orchestra Pit Goal In Life
  04/23/18
...
splenetic degenerate
  04/24/18
Longest lived people are okinawans and their grown men eat a...
splenetic degenerate
  04/24/18
it works in humans too. https://dukespace.lib.duke.edu/ds...
odious stage chad
  04/24/18
...
garnet rough-skinned legend
  04/23/18
calorie restriction retards aging in many species, including...
odious stage chad
  04/22/18
How many calories are you supposed to eat for it to be consi...
offensive idiot
  04/22/18
1500 for a man is about right. At least in mice the lifespan...
odious stage chad
  04/22/18
Yeah totally, starving yourself is a great way to live a lon...
histrionic keepsake machete abode
  04/22/18
That's why I said right before starvation. The optimal diet ...
odious stage chad
  04/22/18
This is highly debatable. The "optimal diet" for w...
histrionic keepsake machete abode
  04/22/18
Optimal in the sense of slowing aging to the maximum extent....
odious stage chad
  04/23/18
Bullet thru brain
Stubborn flatulent address sex offender
  04/22/18
Most effective solution ITT to stop aging.
Pale Hissy Fit
  04/23/18
be underweight, get 9 hours sleep a night, work out, maintai...
nighttime sticky water buffalo hell
  04/22/18
...
coiffed tanning salon
  04/23/18
Vitamin D?
Charismatic temple
  04/23/18
Entropy is slowing down your aging, and will eventually resu...
onyx floppy set
  04/22/18
So, let's define aging as the accumulation of damage in the ...
histrionic keepsake machete abode
  04/22/18
Aging is an epigenetic program and not the result of damage ...
odious stage chad
  04/22/18
can you explain for the layman
Salmon exciting fat ankles market
  04/22/18
there are a number of different theories of aging. many of t...
odious stage chad
  04/22/18
But with respect to number 1, aren't we talking about a meas...
histrionic keepsake machete abode
  04/23/18
it's suggestive evidence. i think the IPSC research is concl...
odious stage chad
  04/23/18
Suggestive yes, I would like to learn more about it though a...
histrionic keepsake machete abode
  04/23/18
i agree with him that epigenetic noise probably doesn't matt...
odious stage chad
  04/23/18
Yes, it's an interesting notion of whether lifespan has a ma...
histrionic keepsake machete abode
  04/23/18
holy shit ty
Salmon exciting fat ankles market
  04/23/18
you might find this interesting. it's about the temporary us...
odious stage chad
  04/23/18
so what you're saying is, I can become a star baby and then,...
Supple Mood Indian Lodge
  04/23/18
There is an epigenetic component of aging, there's no questi...
histrionic keepsake machete abode
  04/22/18
i think most of those hallmarks are related to epigenetic dy...
odious stage chad
  04/23/18
another interesting data point is that naked mole rats have ...
odious stage chad
  04/23/18
The mole rats are definitely fascinating, similarly the lack...
histrionic keepsake machete abode
  04/23/18
there are actually high levels of oxidative damage in naked ...
odious stage chad
  04/24/18
The only 100% not flame scientifically verifiable is to trav...
Salmon exciting fat ankles market
  04/22/18
This won't slow your aging, other people will age more rapid...
histrionic keepsake machete abode
  04/22/18
life is all about appearances
Salmon exciting fat ankles market
  04/22/18
All that happened was time moved more rapidly for everyone e...
histrionic keepsake machete abode
  04/22/18
Thats all OP wants. He's a really nasty man.
Salmon exciting fat ankles market
  04/22/18
Well the joke's on him then
histrionic keepsake machete abode
  04/22/18
nothing ridiculous about that theory at all lol
Slate chapel
  04/23/18
...
Misunderstood crotch codepig
  04/23/18
...
unhinged passionate yarmulke
  04/22/18
Eat food sprayed with glycophate.
onyx floppy set
  04/22/18
Eat. Pray. Love.
onyx floppy set
  04/22/18
...
Thirsty amethyst preventive strike
  04/22/18
Travel at the speed of light
cruel-hearted pit
  04/23/18
...
garnet rough-skinned legend
  04/23/18
Niagen + MitoQ
lavender flickering principal's office
  04/23/18
8-9 hours of sleep every night minimize stress don't b...
Provocative orchid meetinghouse dog poop
  04/23/18
Testosterone, chiropractic care, thyroid supps, therapeutic ...
big ruddy den trust fund
  04/23/18
what kind of chiropractic care? what should he ask for?
wonderful factory reset button point
  04/23/18
I've done Gonstead and am seeing a diversified chiro right n...
big ruddy den trust fund
  04/23/18
you're talking to a guy who literally recommended bloodletti...
Free-loading buck-toothed casino sweet tailpipe
  04/23/18
It's a valid treatment for polycythemia and that's a side ef...
big ruddy den trust fund
  04/23/18
Have frequent novel life experiences and meaningful relation...
judgmental diverse boistinker
  04/23/18
1st one = cr
razzle-dazzle university
  04/23/18
Eat less, maintain low BMI (like 18) Sleep enough Avoid th...
coiffed tanning salon
  04/23/18
eat foods with lots of preservatives--canned, packaged etc
autistic trump supporter party of the first part
  04/23/18
...
abnormal harsh jew people who are hurt
  04/24/18
...
Galvanic Carmine International Law Enforcement Agency Hairy Legs
  04/24/18
1200 calories per day, not flame
Copper sick ticket booth toilet seat
  04/23/18
CRON is unproven
Jet-lagged stock car
  04/23/18
eat legumes often
Jet-lagged stock car
  04/23/18
Science has shown that blood transfusions from younger peopl...
glittery piazza
  04/23/18
The parabiosis experiments don't look very convincing. I don...
odious stage chad
  04/23/18


Poast new message in this thread



Reply Favorite

Date: April 22nd, 2018 9:55 PM
Author: Violent Knife Stage



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897127)



Reply Favorite

Date: April 22nd, 2018 9:59 PM
Author: Slate chapel

sunscreen

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897148)



Reply Favorite

Date: April 22nd, 2018 10:00 PM
Author: Violent Knife Stage

The label says it may contain a carcinogen

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897160)



Reply Favorite

Date: April 22nd, 2018 11:06 PM
Author: Slate chapel

The sun is a verified carcinogen

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897532)



Reply Favorite

Date: April 22nd, 2018 11:11 PM
Author: onyx floppy set

Isn't sunscreen worse tho?

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897552)



Reply Favorite

Date: April 22nd, 2018 11:26 PM
Author: Slate chapel

Uh no? It's pretty much accepted as a necessary daily skin care protectant

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897662)



Reply Favorite

Date: April 22nd, 2018 11:36 PM
Author: onyx floppy set

DAILY??? Obvious Jew scam.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897734)



Reply Favorite

Date: April 23rd, 2018 9:23 AM
Author: Violent Orchestra Pit Goal In Life

lol who the fuck on this website is spending enough time in the sun for it to matter

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35899091)



Reply Favorite

Date: April 22nd, 2018 10:00 PM
Author: fiercely-loyal poppy dysfunction wrinkle

reduce stress

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897158)



Reply Favorite

Date: April 22nd, 2018 10:01 PM
Author: Violent Knife Stage

I live in a joo dominated country full of niggers.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897168)



Reply Favorite

Date: April 23rd, 2018 1:27 AM
Author: judgmental diverse boistinker

Impossible.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898303)



Reply Favorite

Date: April 22nd, 2018 10:05 PM
Author: thriller resort

Rape children, drink their blood

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897194)



Reply Favorite

Date: April 22nd, 2018 10:18 PM
Author: Claret bateful school cafeteria

dont forget to harvest their adrenochrome

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897258)



Reply Favorite

Date: April 22nd, 2018 11:06 PM
Author: onyx floppy set

My first thought too.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897533)



Reply Favorite

Date: April 22nd, 2018 10:18 PM
Author: translucent field immigrant

Meditate, ginseng, green tea, not eating processed shit, eating fresh fruits/veggies raw, not eating meat (fish is great), not eating starchy shit, physical activity, sleeping enough/well, drinking 1.5-2 liters of water (more if lots of activity or in the heat), cutting back on alcohol/smoking.

The body is a machine. The more you abuse it the quicker it breaks down.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897257)



Reply Favorite

Date: April 23rd, 2018 2:52 AM
Author: talented wine digit ratio

Sleep is the only thing from this list that matters

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898537)



Reply Favorite

Date: April 23rd, 2018 8:02 AM
Author: titillating haunting business firm gaping

And H2o, unfortunately.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898893)



Reply Favorite

Date: April 22nd, 2018 10:25 PM
Author: costumed associate trailer park

lift weights. eat healthily. bang your wife often and vigorously.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897287)



Reply Favorite

Date: April 22nd, 2018 10:33 PM
Author: bright office

Sleep a lot

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897326)



Reply Favorite

Date: April 22nd, 2018 10:34 PM
Author: garnet rough-skinned legend

seems tcr

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897332)



Reply Favorite

Date: April 23rd, 2018 8:02 AM
Author: contagious range persian



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898892)



Reply Favorite

Date: April 22nd, 2018 10:35 PM
Author: splenetic degenerate

calorie restriction

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897336)



Reply Favorite

Date: April 22nd, 2018 10:36 PM
Author: costumed associate trailer park

not worth it

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897343)



Reply Favorite

Date: April 22nd, 2018 10:36 PM
Author: splenetic degenerate

probably but its the only one with actual science

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897349)



Reply Favorite

Date: April 22nd, 2018 11:04 PM
Author: costumed associate trailer park

agree there.

still not worth it.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897511)



Reply Favorite

Date: April 22nd, 2018 11:05 PM
Author: histrionic keepsake machete abode

(guy who think studies on monkeys and worms necessarily translate to same effects in humans)

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897518)



Reply Favorite

Date: April 23rd, 2018 9:26 AM
Author: Violent Orchestra Pit Goal In Life

(guy who think humans aren't monkeys)

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35899097)



Reply Favorite

Date: April 24th, 2018 6:16 PM
Author: splenetic degenerate



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35911646)



Reply Favorite

Date: April 24th, 2018 6:17 PM
Author: splenetic degenerate

Longest lived people are okinawans and their grown men eat about 1900/calories

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35911650)



Reply Favorite

Date: April 24th, 2018 12:30 AM
Author: odious stage chad

it works in humans too.

https://dukespace.lib.duke.edu/dspace/bitstream/handle/10161/15069/Belsky%20et%20al.%202017%20J%20Geron%20A_Change%20in%20the%20Rate%20of%20Biological%20Aging%20in%20Response%20to%20Caloric%20Restriction-%20CALERIE%20Biobank%20Analysis.pdf?sequence=1

it's probably something like 8-13 years of lifespan by itself, so nothing too dramatic.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35906203)



Reply Favorite

Date: April 23rd, 2018 12:27 AM
Author: garnet rough-skinned legend



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898099)



Reply Favorite

Date: April 22nd, 2018 10:48 PM
Author: odious stage chad

calorie restriction retards aging in many species, including primates like rhesus monkeys and lemurs. the results on lemurs came out pretty recently and were fairly large (50% gain in lifespan), which is surprising considering they are long lived and the gains in rhesus monkeys were more like 10%. CR is unlikely to work that well in humans, but i would bet it works to some extent.

there are CR mimetic drugs too. rapamycin is one that probably works. metformin might as well, but it doesn't work nearly as consistently as rapamycin. there is some reason to believe that rapamycin might be synergistic with CR, so lifespan gains might be additive if you were willing to do both.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897414)



Reply Favorite

Date: April 22nd, 2018 11:02 PM
Author: offensive idiot

How many calories are you supposed to eat for it to be considered restriction

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897499)



Reply Favorite

Date: April 22nd, 2018 11:11 PM
Author: odious stage chad

1500 for a man is about right. At least in mice the lifespan gains increase until right before the point of starvation.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897551)



Reply Favorite

Date: April 22nd, 2018 11:21 PM
Author: histrionic keepsake machete abode

Yeah totally, starving yourself is a great way to live a long time.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897625)



Reply Favorite

Date: April 22nd, 2018 11:27 PM
Author: odious stage chad

That's why I said right before starvation. The optimal diet provides the absolute minimum number of calories for survival. This appears to be the case in mice. Obviously this isn't feasible to implement in humans

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897664)



Reply Favorite

Date: April 22nd, 2018 11:47 PM
Author: histrionic keepsake machete abode

This is highly debatable. The "optimal diet" for what exactly? One would assume the diet would have to meet all other nutritional needs and the negatives of a diet could outweigh or negate the longevity gains, if there would even be any, at such a low calorie intake. "Low calorie" in general is good, low/healthy BMI is a 'decent' general measure, there's no evidence being near starving is the optimal state for the human body.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897834)



Reply Favorite

Date: April 23rd, 2018 1:29 PM
Author: odious stage chad

Optimal in the sense of slowing aging to the maximum extent. I qualified it by saying this was true for mice. Whether it is also true for humans is unclear.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35901009)



Reply Favorite

Date: April 22nd, 2018 11:00 PM
Author: Stubborn flatulent address sex offender

Bullet thru brain

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897487)



Reply Favorite

Date: April 23rd, 2018 1:51 PM
Author: Pale Hissy Fit

Most effective solution ITT to stop aging.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35901257)



Reply Favorite

Date: April 22nd, 2018 11:07 PM
Author: nighttime sticky water buffalo hell

be underweight, get 9 hours sleep a night, work out, maintain maximum blood serum levels of vitamin :D

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897534)



Reply Favorite

Date: April 23rd, 2018 1:33 AM
Author: coiffed tanning salon



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898320)



Reply Favorite

Date: April 23rd, 2018 1:36 PM
Author: Charismatic temple

Vitamin D?

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35901080)



Reply Favorite

Date: April 22nd, 2018 11:10 PM
Author: onyx floppy set

Entropy is slowing down your aging, and will eventually result in the heat death of the universe.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897544)



Reply Favorite

Date: April 22nd, 2018 11:13 PM
Author: histrionic keepsake machete abode

So, let's define aging as the accumulation of damage in the body.

How do we limit or slow the way we accrue this damage? This damage mainly occurs at the cellular (or smaller) level.

With 2018 technology, there aren't many ways to slow down aging but there are some things you can do. There are also technologies in development that could change the game in the coming decades and prevent or even reverse damage to keep the body in a youthful state, akin to getting a tune up on your car or certain parts replaced.

But for now, what's most important is:

1) do not smoke

2) do not do drugs

3) drink in moderation, if at all. Moderate drinking has been linked to beneficial effects.

4) SLEEP (7-8 hours) More or less than this, generally, is linked to negative outcomes.

5) Stress reduction (laugh, get a massage, take mental health days, meditate, yoga, see a show, do something that makes you happy)

6) Diet & exercise (the two most important by far) In terms of diet, vegetarian or Mediterranean are most associated with longevity gains. Contrary to popular belief, you can get all the protein you need quite easily eating a veg diet.

7) Do not go into the sun, use sunscreen on the beach always. The sun causes irreversible damage to skin as well as wrinkles.

8) Get regular check ups for markers of disease.

9) Floss and take care of your teeth

8) Eat foods high in antioxidants that scavenge free radicals in the body.

In the coming decades, treatments may become available that can "treat" aging on a cellular level. For more information on this, look at someone like Aubrey De Grey who has made that his life's work, along with the SENS foundation. It's pretty fascinating. He doesn't advocate immortality (not achievable) but we can slow or perhaps one day, entirely reverse "aging".

*cue Rod Stewart's Forever Young*

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897571)



Reply Favorite

Date: April 22nd, 2018 11:24 PM
Author: odious stage chad

Aging is an epigenetic program and not the result of damage accumulation. This seems obvious to me based on Hovarth's clock and the induced pluripotent stem cell research that shows restoration of the young phenotype in old cells. There is undoubtedly a stochastic damage component, but it is probably not important - people could conceivably live for hundreds of years without addressing it.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897642)



Reply Favorite

Date: April 22nd, 2018 11:28 PM
Author: Salmon exciting fat ankles market

can you explain for the layman

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897671)



Reply Favorite

Date: April 22nd, 2018 11:57 PM
Author: odious stage chad

there are a number of different theories of aging. many of the common ones that researchers cling to are clearly deeply flawed (free radical theory of aging being the major one). until pretty recently i think it's been a reasonable debate, but over the last 10 years two things have happened:

1. Horvath's clock was created based on epigenetic changes. over time there are highly regular changes in cellular gene expression that can be used to reliably predict chronological age and (more importantly) mortality. this is a much more accurate predictor of mortality than other indicators of biological age (like telomere length). this suggests that epigenetic changes play an important role in the aging process.

https://en.wikipedia.org/wiki/Epigenetic_clock

2. induced pluripotent stem cells are stem cells that have been generated from adult cells. they basically take an old cell and expose it to different proteins, and the cell dedifferentiates (loses its cellular identity, so it becomes a pluripotent stem cell again). the interesting thing about this process is that the aged cells start looking very much like young ones, and the only real change happening is related to epigenetics.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219229/

Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a unique opportunity to derive patient-specific stem cells with potential applications in tissue replacement therapies and without the ethical concerns of human embryonic stem cells (hESCs). However, cellular senescence, which contributes to aging and restricted longevity, has been described as a barrier to the derivation of iPSCs. Here we demonstrate, using an optimized protocol, that cellular senescence is not a limit to reprogramming and that age-related cellular physiology is reversible. Thus, we show that our iPSCs generated from senescent and centenarian cells have reset telomere size, gene expression profiles, oxidative stress, and mitochondrial metabolism, and are indistinguishable from hESCs.

they have already done research on temporarily exposing mice cells to OSKM factors (the factors used to create IPSCs). it significantly lengthened their maximum lifespans. these were mice that had an accelerated aging disease, but i will be very surprised if the results don't carry over to normal mice and humans. the tricky thing will be figuring out optimal dosage schedules and delivery mechanisms - you don't want cells to completely dedifferentiate.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897918)



Reply Favorite

Date: April 23rd, 2018 12:06 AM
Author: histrionic keepsake machete abode

But with respect to number 1, aren't we talking about a measure and not a direct cause? A reliable measure sure, but is it the main thing driving aging? Where is the evidence for that?

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897977)



Reply Favorite

Date: April 23rd, 2018 12:09 AM
Author: odious stage chad

it's suggestive evidence. i think the IPSC research is conclusive - i can't think of a reasonable alternative interpretation.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897998)



Reply Favorite

Date: April 23rd, 2018 12:21 AM
Author: histrionic keepsake machete abode

Suggestive yes, I would like to learn more about it though and the science of how/why it's "driving" the aging, that's the part that needs to be discovered. It's also possible it's a variety of factors.

FWIW, here's de Grey's take:

Feinerman: There is growing evidence that epigenetic changes are highly organized and may be one of the causes of ageing. What do you think? Maybe should we consider epigenetic changes as another type of damage in SENS model, calling EpiSENS?

de Grey: We need to be much more precise with definitions in order to answer your question. Epigenetic changes can be classified into two main classes: shift and noise. Shift means changes that occur in a coordinated manner among all cells of a given type and tissue, whereas noise means changes that occur in some such cells but not others, increasing the variability of that type of cell. Shifts are caused by some sort of program (genetic changes to the cell's environment), so yes, they can potentially be reversed by restoring the environment and putting the program into reverse. Noise, on the other hand, is not reversible. And we have for several years worked on determining whether it happens enough to matter in a currently normal lifetime. We have not got to a definitive answer, but it's looking though no, epigenetic noise accumulates too slowly to matter, other than maybe for cancer (which, of course, we are addressing in other ways).

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898068)



Reply Favorite

Date: April 23rd, 2018 12:27 AM
Author: odious stage chad

i agree with him that epigenetic noise probably doesn't matter much. the DNA methylation changes at Cpg islands appear to be highly regular and predictable. it looks like a cellular program to me - the body is self-destructing either because of antagonistic pleiotropy or programmed aging.

i should note that i am not against the SENS program - senolytics in particular will likely yield near-term health benefits. i just think that in order to increase maximum lifespan significantly epigenetic changes will have to be addressed.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898097)



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Date: April 23rd, 2018 12:38 AM
Author: histrionic keepsake machete abode

Yes, it's an interesting notion of whether lifespan has a maximum or could be continued indefinitely - in de Grey's case, he would postulate continuous rejuvenation (hence, no hard limit) but I am not yet sold on this either. If some mammals "age" while something like the mole rat really does not seem to age, this mechanism needs to be better understood and what its impact truly is.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898149)



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Date: April 23rd, 2018 12:13 AM
Author: Salmon exciting fat ankles market

holy shit

ty

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898020)



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Date: April 23rd, 2018 12:20 AM
Author: odious stage chad

you might find this interesting. it's about the temporary use of OSKM factors.

https://www.scientificamerican.com/article/aging-is-reversible-at-least-in-human-cells-and-live-mice/

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898058)



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Date: April 23rd, 2018 12:25 AM
Author: Supple Mood Indian Lodge

so what you're saying is, I can become a star baby and then, eventually, a motherfucking starboy?

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898083)



Reply Favorite

Date: April 22nd, 2018 11:41 PM
Author: histrionic keepsake machete abode

There is an epigenetic component of aging, there's no question some genes are linked to longer lifespans and others to shorter ones for a plethora of reasons based on what they do or do not do when expressed. Our genetic make up is a stochastic component as much as damage is, but regardless of certain genes, aging is defined primarily as the accumulation of damage in the body to the point where disease states emerge. How do you address that problem? SENS for example offers 7 problems to address appropriately to bring about "negligible senescence'

1)cell loss or atrophy (without replacement)

2)oncogenic nuclear mutations and epimutations

3)cell senescence (Death-resistant cells)

4)mitochondrial mutations

5)Intracellular junk or junk inside cells (lysosomal aggregates)

6)extracellular junk or junk outside cells (extracellular aggregates)

7)random extracellular cross-linking

DNA methylation can certainly be used to determine or estimate the biological age of a tissue but the global loss of methylation via aging is something that can be reduced or prevented under the umbrella of the problems identified above. It's more of a measure than something that is a primary means or cause of aging.

Edit: Another example is telomere length. Say we find a way to re-lengthen as they become shorter with age and shorter telomeres are a sign of aging. If we lengthen to a more "youthful" state you'd measure a younger biological age. It's both an indicator and effect of aging that can be reversed, but also useful as a measure.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897778)



Reply Favorite

Date: April 23rd, 2018 12:06 AM
Author: odious stage chad

i think most of those hallmarks are related to epigenetic dysfunction or aren't very important.

"DNA methylation can certainly be used to determine or estimate the biological age of a tissue but the global loss of methylation via aging is something that can be reduced or prevented under the umbrella of the problems identified above. It's more of a measure than something that is a primary means or cause of aging. "

there's little reason to believe that DNA methylation changes can be prevented or reversed through the SENS strategies.

the interpretation that epigenetic changes are simply an indicator of damage doesn't make much sense. if this was the case, we wouldn't expect to see dramatic reversal of the aged phenotype through cellular reprogramming.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219229/



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897975)



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Date: April 23rd, 2018 12:08 AM
Author: odious stage chad

another interesting data point is that naked mole rats have very stable epigenomes and also display negligible senescence. they still accumulate damages like senescent cells, but it doesn't seem to matter. the stable epigenome prevents significant tissue dysfunction.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897989)



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Date: April 23rd, 2018 12:33 AM
Author: histrionic keepsake machete abode

The mole rats are definitely fascinating, similarly the lack of cancer in elephants. This could still be a result of extremely efficient repair of DNA/protein damage relative to most other existing mammals, but it's very neat stuff.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898130)



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Date: April 24th, 2018 12:34 AM
Author: odious stage chad

there are actually high levels of oxidative damage in naked mole rats. they have less efficient DNA repair than mice, which have considerably shorter lifespans.

again, it has to do with the stability of the epigenome. naked mole rats have stable gene expression patterns.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35906234)



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Date: April 22nd, 2018 11:16 PM
Author: Salmon exciting fat ankles market

The only 100% not flame scientifically verifiable is to travel as close to the speed of light as you can.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897594)



Reply Favorite

Date: April 22nd, 2018 11:17 PM
Author: histrionic keepsake machete abode

This won't slow your aging, other people will age more rapidly in relation to you due to the speed at which you're moving, but that won't impact the rate at which you, yourself, age.

hth! xoxo

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897604)



Reply Favorite

Date: April 22nd, 2018 11:25 PM
Author: Salmon exciting fat ankles market

life is all about appearances

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897649)



Reply Favorite

Date: April 22nd, 2018 11:27 PM
Author: histrionic keepsake machete abode

All that happened was time moved more rapidly for everyone else than it did for you, relative to them. So you travel at light speed for a year, but a hundred years passed on earth. You didn't slow aging, everyone else just aged and died really fast from your POV.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897665)



Reply Favorite

Date: April 22nd, 2018 11:29 PM
Author: Salmon exciting fat ankles market

Thats all OP wants. He's a really nasty man.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897674)



Reply Favorite

Date: April 22nd, 2018 11:42 PM
Author: histrionic keepsake machete abode

Well the joke's on him then

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897794)



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Date: April 23rd, 2018 12:11 AM
Author: Slate chapel

nothing ridiculous about that theory at all lol

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898008)



Reply Favorite

Date: April 23rd, 2018 12:48 AM
Author: Misunderstood crotch codepig



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898186)



Reply Favorite

Date: April 22nd, 2018 11:16 PM
Author: unhinged passionate yarmulke



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897597)



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Date: April 22nd, 2018 11:17 PM
Author: onyx floppy set

Eat food sprayed with glycophate.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897602)



Reply Favorite

Date: April 22nd, 2018 11:18 PM
Author: onyx floppy set

Eat. Pray. Love.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897614)



Reply Favorite

Date: April 22nd, 2018 11:41 PM
Author: Thirsty amethyst preventive strike



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897785)



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Date: April 23rd, 2018 12:07 AM
Author: cruel-hearted pit

Travel at the speed of light

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35897982)



Reply Favorite

Date: April 23rd, 2018 12:27 AM
Author: garnet rough-skinned legend



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898104)



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Date: April 23rd, 2018 12:13 AM
Author: lavender flickering principal's office

Niagen + MitoQ

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898022)



Reply Favorite

Date: April 23rd, 2018 12:39 AM
Author: Provocative orchid meetinghouse dog poop

8-9 hours of sleep every night

minimize stress

don't be fat

eat a diet that is actually rich in fresh vegetables, particularly cruciferous vegetables and other greens. you don't NEED to be a vegetarian unless you can't otherwise regulate your animal product intake to reasonable levels

don't be addicted to poison and nicotine

exercise and stay active

maintain a network of friends and family who you see regularly and enjoy spending time with

that's about as good as you're going to get. all the supplements and bizarre fads and minutia are easily overwhelmed by genetics and daily lifestyle factors you will never be aware of.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898152)



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Date: April 23rd, 2018 12:45 AM
Author: big ruddy den trust fund

Testosterone, chiropractic care, thyroid supps, therapeutic phlebotomy

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898171)



Reply Favorite

Date: April 23rd, 2018 1:29 AM
Author: wonderful factory reset button point

what kind of chiropractic care? what should he ask for?

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898308)



Reply Favorite

Date: April 23rd, 2018 1:35 AM
Author: big ruddy den trust fund

I've done Gonstead and am seeing a diversified chiro right now out of lack of other choices.

Structural is another variant to look at as well.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898323)



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Date: April 23rd, 2018 3:13 AM
Author: Free-loading buck-toothed casino sweet tailpipe

you're talking to a guy who literally recommended bloodletting

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898562)



Reply Favorite

Date: April 23rd, 2018 4:49 AM
Author: big ruddy den trust fund

It's a valid treatment for polycythemia and that's a side effect of supplementing T

Also hemochromatosis

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898656)



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Date: April 23rd, 2018 1:29 AM
Author: judgmental diverse boistinker

Have frequent novel life experiences and meaningful relationships with a close social group.

Basically the opposite of living like a lawyer.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898310)



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Date: April 23rd, 2018 8:13 AM
Author: razzle-dazzle university

1st one = cr

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898919)



Reply Favorite

Date: April 23rd, 2018 1:34 AM
Author: coiffed tanning salon

Eat less, maintain low BMI (like 18)

Sleep enough

Avoid the sun

Not be pure white

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898321)



Reply Favorite

Date: April 23rd, 2018 7:59 AM
Author: autistic trump supporter party of the first part

eat foods with lots of preservatives--canned, packaged etc

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898884)



Reply Favorite

Date: April 24th, 2018 12:31 AM
Author: abnormal harsh jew people who are hurt



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35906217)



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Date: April 24th, 2018 12:39 AM
Author: Galvanic Carmine International Law Enforcement Agency Hairy Legs



(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35906266)



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Date: April 23rd, 2018 8:01 AM
Author: Copper sick ticket booth toilet seat

1200 calories per day, not flame

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35898886)



Reply Favorite

Date: April 23rd, 2018 9:30 AM
Author: Jet-lagged stock car

CRON is unproven

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35899117)



Reply Favorite

Date: April 23rd, 2018 9:29 AM
Author: Jet-lagged stock car

eat legumes often

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35899115)



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Date: April 23rd, 2018 10:18 AM
Author: glittery piazza

Science has shown that blood transfusions from younger people can help “reverse” aging.

https://www.scientificamerican.com/article/fountain-of-youth-young-blood-infusions-ldquo-rejuvenate-rdquo-old-mice/

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35899357)



Reply Favorite

Date: April 23rd, 2018 1:25 PM
Author: odious stage chad

The parabiosis experiments don't look very convincing. I don't believe they have extended lifespan despite some indicators of improved health.

(http://www.autoadmit.com/thread.php?thread_id=3956869&forum_id=2#35900965)