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Is daily use of melatonin safe?

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Heady gold feces
  12/10/18
it seems to have health benefits in mice models. I wouldn't ...
Pale free-loading boltzmann
  12/10/18
What's considered a giant dose?
Bat-shit-crazy azn home
  12/10/18
More than 5mg. There is no reason to take 10mg. It is effect...
Pale free-loading boltzmann
  12/10/18
Good just checked mine and it’s only 3mg
Bat-shit-crazy azn home
  12/10/18
No it ruined my life for a couple years not flame
talking obsidian stage faggotry
  12/10/18
Please explain
Big dopamine masturbator
  12/10/18
...
Heady gold feces
  12/10/18
...
Bat-shit-crazy azn home
  12/10/18
took it for a while and my body stopped producing it natural...
talking obsidian stage faggotry
  12/10/18
JFC. how much were you taking each night?
Heady gold feces
  12/10/18
Not much, like 1 pill or whatever. The stuff is bad news
talking obsidian stage faggotry
  12/10/18
This is flame. Melatonin is found in a bunch of foods. A tin...
Purple marvelous ticket booth
  12/10/18
Yeah, this dood had other reasons for getting fuked up, not ...
Sinister den
  12/10/18
Not flame at all. And the amount in food is measured in nano...
talking obsidian stage faggotry
  12/10/18
Did you stop for a week after 60 days of use? That is what y...
Sinister den
  12/10/18
Same. Still can't get deep sleep
mind-boggling arrogant piazza
  12/10/18
...
talking obsidian stage faggotry
  12/10/18
I take 10MG every night. Hopefully it is safe.
talented domesticated school cafeteria
  12/10/18
Lol no. Stop taking it immediately. Take magnesium or ZMA i...
Beady-eyed French Abode
  12/10/18
I’ve been taking 3mg/night for years and am kinda depe...
Aphrodisiac selfie principal's office
  12/10/18
What is the right dose of melatonin? 0.3 mg. http://sl...
Flushed legal warrant hall
  12/10/18
...
talking obsidian stage faggotry
  12/10/18
I started trying it about 2 months ago in 180AZIA. That shit...
Sinister den
  12/10/18


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Date: December 10th, 2018 3:59 PM
Author: Heady gold feces



(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37384021)



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Date: December 10th, 2018 4:02 PM
Author: Pale free-loading boltzmann

it seems to have health benefits in mice models. I wouldn't take the giant doses many supplement manufacturers use though

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37384038)



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Date: December 10th, 2018 4:02 PM
Author: Bat-shit-crazy azn home

What's considered a giant dose?

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37384042)



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Date: December 10th, 2018 4:06 PM
Author: Pale free-loading boltzmann

More than 5mg. There is no reason to take 10mg. It is effective at low doses.

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37384065)



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Date: December 10th, 2018 8:54 PM
Author: Bat-shit-crazy azn home

Good just checked mine and it’s only 3mg

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37385728)



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Date: December 10th, 2018 4:03 PM
Author: talking obsidian stage faggotry

No it ruined my life for a couple years not flame

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37384050)



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Date: December 10th, 2018 4:07 PM
Author: Big dopamine masturbator

Please explain

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37384069)



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Date: December 10th, 2018 4:22 PM
Author: Heady gold feces



(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37384156)



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Date: December 10th, 2018 4:26 PM
Author: Bat-shit-crazy azn home



(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37384173)



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Date: December 10th, 2018 4:46 PM
Author: talking obsidian stage faggotry

took it for a while and my body stopped producing it naturally and i developed horrible insomnia and it took a couple years to feel normal again. i would never fuck with this stuff or any kind of sleep aid again

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37384294)



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Date: December 10th, 2018 7:45 PM
Author: Heady gold feces

JFC. how much were you taking each night?

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37385342)



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Date: December 10th, 2018 9:23 PM
Author: talking obsidian stage faggotry

Not much, like 1 pill or whatever. The stuff is bad news

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37385940)



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Date: December 10th, 2018 9:32 PM
Author: Purple marvelous ticket booth

This is flame. Melatonin is found in a bunch of foods. A tiny 3-5 mg melatonin supplement is not going to fuck up your sleep habits.

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37386018)



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Date: December 10th, 2018 9:33 PM
Author: Sinister den

Yeah, this dood had other reasons for getting fuked up, not this shit.

Oh and its natural for your body to reduce producing melotonin as you age. By mid 30's your body only produces less than half what it did at 25:

There is a constant diminution of melatonin production from age 10 onwards . The production of melatonin is so low in the 60’s that most people would do well supplementing with about 3 mg of melatonin at bedtime.

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37386028)



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Date: December 10th, 2018 9:37 PM
Author: talking obsidian stage faggotry

Not flame at all. And the amount in food is measured in nanograms

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37386075)



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Date: December 10th, 2018 9:29 PM
Author: Sinister den

Did you stop for a week after 60 days of use? That is what youre supposed to do to get your body non dependent on it.

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37385988)



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Date: December 10th, 2018 9:07 PM
Author: mind-boggling arrogant piazza

Same. Still can't get deep sleep

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37385802)



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Date: December 10th, 2018 9:23 PM
Author: talking obsidian stage faggotry



(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37385935)



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Date: December 10th, 2018 4:11 PM
Author: talented domesticated school cafeteria

I take 10MG every night. Hopefully it is safe.

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37384096)



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Date: December 10th, 2018 8:55 PM
Author: Beady-eyed French Abode

Lol no.

Stop taking it immediately. Take magnesium or ZMA instead.

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37385741)



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Date: December 10th, 2018 9:05 PM
Author: Aphrodisiac selfie principal's office

I’ve been taking 3mg/night for years and am kinda dependent on it to sleep. But back in the 90s they were saying it’s a new wonder drug and fountain of youth so hopefully that will be borne out.

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37385795)



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Date: December 10th, 2018 9:24 PM
Author: Flushed legal warrant hall

What is the right dose of melatonin?

0.3 mg.

http://slatestarcodex.com/blog_images/melatonin1.jpeg

“But my local drugstore sells 10 mg pills! When I asked if they had anything lower, they looked through their stockroom and were eventually able to find 3 mg pills! And you’re saying the correct dose is a third of a milligram?!”

Yes. Most existing melatonin tablets are around ten to thirty times the correct dose.

Many early studies were done on elderly people, who produce less endogenous melatonin than young people and so are considered especially responsive to the drug. Several lines of evidence determined that 0.3 mg was the best dose for this population. Elderly people given doses around 0.3 mg slept better than those given 3 mg or more and had fewer side effects (Zhdanova et al 2001). A meta-analysis of dose-response relationships concurred, finding a plateau effect around 0.3 mg, with doses after that having no more efficacy, but worse side effects (Brzezinski et al, 2005). And doses around 0.3 mg cause blood melatonin spikes most similar in magnitude and duration to the spikes seen in healthy young people with normal sleep (Vural et al, 2014).

Other studies were done on blind people, who are especially sensitive to melatonin since they lack light cues to entrain their circadian rhythms. This is a little bit of a different indication, since it’s being used more as a chronobiotic than a sleeping pill, but the results were very similar: lower doses worked better than higher doses. For example, in Lewy et al 2002, nightly doses of 0.5 mg worked to get a blind subject sleeping normally at night; doses of 20 mg didn’t. They reasonably conclude that the 20 mg is such a high dose that it stays in their body all day, defeating the point of a hormone whose job is to signal nighttime. Other studies on the blind have generally confirmed that doses of around 0.3 to 0.5 mg are optimal.

There have been disappointingly few studies on sighted young people. One such, Attenburrow et al 1996 finds that 1 mg works but 0.3 mg doesn’t, suggesting these people may need slightly higher doses, but this study is a bit of an outlier. Another Zhdanova study on 25 year olds found both to work equally. And Pires et al studying 22-24 year olds found that 0.3 mg worked better than 1.0. I am less interested in judging the 0.3 mg vs. 1.0 mg debate than in pointing out that both numbers are much lower than the 3 – 10 mg doses found in the melatonin tablets sold in drugstores.

UpToDate, the gold standard research database used by doctors, agrees with these low doses. “We suggest the use of low, physiologic doses (0.1 to 0.5 mg) for insomnia or jet lag (Grade 2B). High-dose preparations raise plasma melatonin concentrations to a supraphysiologic level and alter normal day/night melatonin rhythms.” Mayo Clinic makes a similar recommendation: they recommend 0.5 mg. John Hopkins’ experts almost agree: they say “less is more” but end up chickening out and recommending 1 to 3 mg, which is well above what the studies would suggest.

Based on a bunch of studies that either favor the lower dose or show no difference between doses, plus clear evidence that 0.3 mg produces an effect closest to natural melatonin spikes in healthy people, plus UpToDate usually having the best recommendations, I’m in favor of the 0.3 mg number. I think you could make an argument for anything up to 1 mg. Anything beyond that and you’re definitely too high. Excess melatonin isn’t grossly dangerous, but tends to produce tolerance and might mess up your chronobiology in other ways. Based on anecdotal reports and the implausibility of becoming tolerant to a natural hormone at the dose you naturally have it, I would guess sufficiently low doses are safe and effective long term, but this is just a guess, and most guidelines are cautious in saying anything after three months or so.

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37385943)



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Date: December 10th, 2018 9:26 PM
Author: talking obsidian stage faggotry



(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37385961)



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Date: December 10th, 2018 9:32 PM
Author: Sinister den

I started trying it about 2 months ago in 180AZIA. That shit is amazing. I take 5mg. I use to sleep at 5 or 6am but now sleep at 1 or 2 or even earlier.

But you shouldn't take it every night. I dont take it on nights when I'm drinking cause I pass out drunk anyway. Like last two nights i didnt drink but I feel asleep normally without using it.

It says not to take it for more than 60 days without breaking for a week.

But it seems 1800000 as shit. I wish I knew abt this crap when I was flying Asia-US all the time, damn

(http://www.autoadmit.com/thread.php?thread_id=4153279&forum_id=2#37386017)