http://www.ehjournal.net/content/11/1/90

Anogenital distance is related to ovarian follicular number in young Spanish women: a cross-sectional study

Background

In animals, anogenital distance (AGD) at birth reflects androgen levels during pregnancy and predicts adult AGD. Little is known about AGD in relation to female reproductive characteristics in humans, a question this study was designed to explore.

Study population

The Murcia Young Women’s Study (MYWS) is a cross-sectional study of healthy young university students (18–23 years old) in the Murcia region of Spain. MYWS was carried out between 9th February 2011 and 25th November 2011. Written informed consent was obtained from all subjects. The Research Ethics Committee of the University of Murcia approved this study.

Flyers stating, “Young healthy female university students wanted for research project” were posted at university campuses to invite students to participate in this study. To be included in MYWS, subjects had to be university students, have been born in Spain after 31st December 1987, and be able to contact their mother and ask her to complete a questionnaire. One hundred and twenty-four students contacted us, 15 subjects did not meet inclusion criteria (3 had not been born in Spain and 12 were born before 31st December, 1987), leaving 109 (88%) eligible students of whom 100 (92%) agreed to participate in the study. At a scheduled clinic visit subjects underwent a gynecological examination, including transvaginal ultrasound, and completed an epidemiological questionnaire on lifestyle. Participants were compensated for their participation (€40 gift card).

Anogenital measurements

For each subject, AGD was measured in two ways. First, AGDAC was measured from the anterior clitoral surface to the center of the anus (Figure 1, point 1 to point 3). Second, AGDAF was measured from the posterior fourchette to the center of the anus (Figure 1, point 2 to point 3). Measurements were made using a digital caliper (Stainless Steel Digital Caliper, VWR® International, LLC, West Chester, PA, USA) and while subjects were in the lithotomy position, with the thighs at a 45° angle to the examination table. To improve precision, two examiners made each of these measurements three times, taking in total 6 measures for AGDAF and AGDAC, respectively. The mean of the six measurements was used as the estimate. Neither the examiners nor the support staff had knowledge of any of the women’s possible conditions/alterations because the AGD measures were taken before the gynecological examination.

Results

Both AGD measures were positively associated with ovarian follicle number, with AGDAF being more strongly associated. Women in the upper tertile of the AGDAF and AGDAC distributions were more likely to have > 6 ovarian follicles [OR: 6.0 (95% CI 2.0, 17.6) and 3.0 (95% CI 1.1, 8.6), respectively] compared to women in the lowest tertile.

Conclusions

Increased follicular recruitment has been related to excess androgen exposure in utero in toxicological studies. Our results suggest that the androgenic environment during early fetal life may influence reproductive system development, including AGD, in human females.

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#27294013)

someone posted a cum DNA ends up in women's brains article recently

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#27294098)

poast link

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#27297918)

Termination of intractable hiccups with digital rectal massage.

Abstract

A 60-year-old man with acute pancreatitis developed persistent hiccups after insertion of a nasogastric tube. Removal of the latter did not terminate the hiccups which had also been treated with different drugs, and several manoeuvres were attempted, but with no success.

Digital rectal massage was then performed resulting in abrupt cessation of the hiccups. Recurrence of the hiccups occurred several hours later, and again, they were terminated immediately with digital rectal massage. No other recurrences were observed.

This is the second reported case associating cessation of intractable hiccups with digital rectal massage. We suggest that this manoeuvre should be considered in cases of intractable hiccups before proceeding with pharmacological agents.

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#28888215)

U: moving commas

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#27294037)

"oh shit, what should we do today bros? we still got grant money left?"

"got some gift cards i guess."

"awesome... let's get some bitches naked."

"right on."

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#27294068)

- Vaginal depth.

- Clitoral length.

- Nipple-areola ratios.

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#27294072)

uunnnngghhh

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#27294116)

"If your mom does ________, you're going to have a ________ taint, which is ________."

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#27294169)

for a $100 gift card.

god bless spain

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#27294283)

(http://www.autoadmit.com/thread.php?thread_id=2805701&forum_id=2Firm#34262104)