The main difference I think between the two bands is that U2 makes a lot more from touring. U2 grossed 750 million on their last tour. As popular as Radiohead is on streaming playlists they don't exactly pack arenas. Bono's theatrics are a selling point. Thom just stands there lifeless. I think U2 plays way more shows too.

Radiohead typically only goes on tour when they have new music and to promote the record, not a feel good greatest hits experience. If Radiohead went on tour and played Creep Karma Police No Surprises High and Dry and Fake Plastic Trees every night they would have made a lot more money. Instead they play The Gloaming and other weird shit. I actually saw them once and they debuted a song for the first time that would be on A Moon Shaped Pool. It was a terrible, terrible song and one that no one in the audience had ever heard before. They are true artists for better or ill. Bono wouldn't dream of playing a show and not playing the hits off of Joshua Tree.

(https://autoadmit.com/thread.php?thread_id=5921293&forum_id=2#50250229)