Colom's tenure has had several notable prosecutions of cold cases. In 2017, Colom's office led the prosecution of David Murray for the 1996 murder of 78-year-old Mack Fowler, who was stabbed to death in his home.[25] In 2020, Colom led the prosecution of Michael Devaughn for the 1990 rape of Kathryn Crigler and the murder of Betty Jones. After evading justice for over 30 years, Devaughn received a life sentence for the murder and rape.[26] In January 2025, Colom prosecuted Frederick Gandy for the 2003 rapes of Amber Quick and Nashedra Strong-Clay. Gandy received a mandatory 25-year sentence.[27]
Colom has achieved convictions in over 95% of his jury trials, including more than 30 significant cases involving murder and sexual assault.[28] In 2017, he successfully prosecuted Terry Hill for the rape, robbery, and kidnapping of a college student at Mississippi State University. Hill was found guilty on all charges and sentenced to 105 years in prison.[29] In September 2018, Colom led the prosecution of Johnny Lee Saddler, who was convicted of molesting an autistic child. Saddler received a life sentence without the possibility of parole as a habitual and subsequent sex offender.[30]
Colom has also secured convictions in numerous high-profile murder cases:
Joshua Taylor for the murder of William Stallings in 2018;[31]
Joshua Murray for the murder of Jarrell Ward in 2020;[32]
Lydia Martinez for her role in the 2015 conspiracy to murder her son-in-law, Manuel Vasquez, and burn his body;[33]
William Thomas Chisholm for capital murder of Shauna Witt;[34]
Donta Kirby for the murder of Lorenzo Halthon, Jr.;[35]
Roderick Johnson for the 2015 murder of James "Fluffy" White;[36]
Clark Allen Jr. for the 2019 capital murders of Demario Snell, Mauricio Nance, and Tyshun Fields;[37]
Curtis Latham for the second-degree murder of Arykah White in 2019;[38]
Jatavis Williams for the 2020 shooting death of Tarcari Walker;[39]
Kenny Armistad for the November 2021 murder of Frank Edwards Jr.;[40]
Tommy Lee Flowers for the murder of Harvey Johnson Jr., under the theory of accomplice liability;[41]
Henry Benamon for first-degree murder in the July 2021 shooting death of Lisa Brooks;[42]
Willis Miller for the aggravated DUI death of Paisley "Gabby" Frazier;[43]
Undra Williams Jr. for the murder of Devon Thompson and three counts of aggravated assault;[44]
Christopher Perkins for the murder of Lasang Kemp Jr.[45]